You'll rarely go wrong in choosing a renderings composition that follow the rules. However, for stepping up the creativity at times, don't get locked into the Rule of Thirds as a hard-and-fast policy. At times, it can be restrictive for those 3D scenes that just don't fit onto a Thirds settings. While the perfect spot fir the subject may be somewhere off-center, for example, it might not necessarily be in one of the power points.
In fact, there are times when a dead-center composition is dead-on. This can be a subject with strong symmetry, such as a wheel, in which the hub is in the middle while the spokes spread out in all directions. When rendering close up, work, too, as does symmetry in most of my architectural renderings. Likewise, some renderings don't even have a specific subject; rather, the entire rendering is the subject, such as a pattern or repetition scenes.